HomeInvestmentVerona Pharma Inventory: An Up to date Funding Thesis (NASDAQ:VRNA)

Verona Pharma Inventory: An Up to date Funding Thesis (NASDAQ:VRNA)

Nyaaka Picture

A watch for an eye fixed will solely make the entire world blind.”― Mahatma Gandhi

We’ve not seemed again on Verona Pharma plc (NASDAQ:VRNA) since our final article on this small biopharma concern from throughout the pond early in 2021. The inventory has had an enormous transfer up over the previous few months on constructive information movement. An up to date evaluation follows beneath.

Stock Chart

In search of Alpha

Firm Overview:

This London-based pre-clinical concern is targeted on the event and commercialization of therapies for the therapy of respiratory ailments with unmet medical wants. The inventory presently trades round $12.50 a share and sports activities an approximate market capitalization of $950 million.

Verona’s main asset inside its pipeline is named ensifentrine. Ensifentrine combines bronchodilator and anti inflammatory properties in a single compound and has the potential to be an efficient therapy for persistent obstructive pulmonary illness or COPD and different respiratory ailments, together with bronchial asthma and cystic fibrosis. The corporate’s main focus for this candidate is COPD at this second. Analysis of ensifentrine by way of a nebulizer to deal with bronchial asthma and cystic fibrosis is in Part two growth.

On October 14th, the corporate disclosed constructive results throughout main and secondary endpoints of lung perform, evaluating ensifentrine in opposition to COPD in a Part 3 examine referred to as ENHANCE-2, which included subgroups. In accordance with the info, use of ensifentrine resulted in a 42% discount within the fee of reasonable to extreme exacerbations noticed within the total inhabitants in comparison with placebo.

This follows encouraging high line outcomes from the identical trial that got here out in August. Outcomes from the same trial ‘ENHANCE-1’ ought to be out by the shut of this 12 months. Roughly 1,600 topics are enrolled in ENHANCE-1 and ENHANCE-2 mixed.

In August, Nuance Pharma, Verona’s growth companion for ensifentrine in China, acquired clearance to start Part 1 and Part 3 research with ensifentrine for COPD in mainland China. Through this advertising and marketing settlement, Verona can obtain as much as practically $180 million in potential milestone payouts along with royalties on any commercialized gross sales.

Analyst Commentary & Stability Sheet:

Since August, 5 analyst companies, together with Piper Sandler and Wedbush, have reissued Purchase scores on VRNA. Two of those contained minor upward worth goal revisions. Worth targets proffered vary from $20 to $31 a share.

Solely two % of the excellent float of the inventory is presently held brief. The corporate raised roughly $150 million by way of a secondary providing in mid-August and ended the third quarter with simply over $230 million of money and marketable securities on its steadiness sheet. The corporate additionally just lately introduced $150 million debt facility from Oxford Finance. This changed a $30 million facility with Silicon Valley Financial institution. Administration acknowledged the next in its press launch that accompanied third quarter leads to regards to its funding standing.

Anticipated money receipts from the UK tax credit score program and funding anticipated to turn into obtainable underneath the $150 million debt facility will allow Verona Pharma to fund deliberate working bills and capital expenditure necessities by at the least the top of 2025 together with the industrial launch of ensifentrine in the US.”

The corporate had a web lack of $15.6 million for the third quarter.


Conditional upon constructive outcomes from ENHANCE-1, the corporate expects to submit an NDA to the FDA within the first half of subsequent 12 months for the upkeep therapy of COPD. This can be a enormous potential buyer base given COPD impacts roughly 25 million People yearly. Over 380 million sufferers endure from COPD worldwide, and it’s the third main reason for loss of life worldwide.

Potential Market

Firm Presentation

There are quite a few COPD merchandise available on the market. The worldwide marketplace for COPD remedies was valued at practically $20 billion in 2021. The inventory is up roughly 40% since our final article on it a 12 months and a half in the past. We concluded that piece with the advice ‘VRNA’s danger/reward profile nonetheless appears prefer it deserves a small holding inside a well-diversified biotech portfolio.’ After revisiting the funding case on this small biopharma, that continues to be our view.

Revenge, the sweetest morsel to the mouth that ever was cooked in hell.― Walter Scott

Supply hyperlink

latest articles

explore more


Please enter your comment!
Please enter your name here